What is the optimal dosage for personal meaning?

What is the difference between leisure and laziness?  There's some factor - accomplishment, ability, or role which allows one to seem deserved and the other criminal.  Yet they are the same activity.

When we ascribe these labels to others, we are stating their deservedness.  When we ascribe them to ourselves, we are stating both our deservedness and also our worth. 

For some, the tragedy of the end of work would be that workers would lose their personal meaning.  My read is that this belief decries workaholism; meaning is available nearly everywhere: from the sublime to the absurd.  

If it's a palliative, then how do we prescribe it to others?  If it's a poison, how do we control its use?  If personal meaning is a good whose absence is costly, what is the minimum effective dose?  If meaning derives from work, what is the minimum effective dose?  And is there such a thing as a placebo - or does all meaning wear the same?